Incidence of H1N1 2009 virus infection through the analysis of paired plasma specimens among blood donors, France.
Identifieur interne : 000161 ( France/Analysis ); précédent : 000160; suivant : 000162Incidence of H1N1 2009 virus infection through the analysis of paired plasma specimens among blood donors, France.
Auteurs : Angie Bone [France] ; Jean-Paul Guthmann [France] ; Azzedine Assal [France] ; Dominique Rousset [France] ; Armelle Degeorges [France] ; Pascal Morel [France] ; Martine Valette [France] ; Vincent Enouf [France] ; Eric Jacquot [France] ; Bertrand Pelletier [France] ; Yann Le Strat [France] ; Josiane Pillonel [France] ; Laure Fonteneau [France] ; Sylvie Van Der Werf [France] ; Bruno Lina [France] ; Pierre Tiberghien [France] ; Daniel Lévy-Bruhl [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
BACKGROUND: Knowledge of the age-specific prevalence of seroprotection and incidence of seroconversion infection is necessary to complement clinical surveillance data and statistical models. It provides the basis for estimating the future impact of influenza A (H1N1pdm09) and implementing appropriate prevention and response strategies. METHODS: Using a cross-sectional design, two-stage stratified sampling and paired plasma samples, we estimated the age-specific prevalence of a protective level of H1N1pdm09 antibodies in the French adult population before and after the 2009/10 pandemic, and the proportion of those susceptible that seroconverted due to infection, from a single sample of 1,936 blood donors aged 20-70 years in mainland France in June 2010. Samples with a haemagglutination inhibition (HI) titre ≥1∶40 were considered seropositive, and seroconversion due to infection was defined as a 4-fold increase in titre in the absence of H1N1pdm09 vaccination or pre-pandemic seropositivity. RESULTS: Out of the 1,936 donors, 1,708 were included in the analysis. Seroprevalence before the pandemic was 6.7% (95% CI 5.0, 8.9) with no significant differences by age-group (p = 0.3). Seroprevalence afterwards was 23.0% (95% CI 17.7, 29.3) with 20-29 year olds having a higher level than older groups (p<0.001). Seroconversion due to infection was 12.2% (95% CI 6.9, 20.5). Younger age-group, vaccination against H1N1 and being seropositive before the pandemic were strongly associated with post-pandemic seropositivity. CONCLUSIONS: Before the 2009/2010 winter influenza season, only 6.7% of the French mainland population aged 20-70 had a level of antibodies usually considered protective. During the first pandemic wave, 12.2% of the population seroconverted due to infection and the seroprevalence after the wave rose to 23%, either due to prepandemic seropositivity, infection or vaccination. This relatively low latter figure contributed to an extension of target groups for influenza vaccination for the 2010/2011 season.
Url:
DOI: 10.1371/journal.pone.0033056
Affiliations:
Links toward previous steps (curation, corpus...)
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Hal:inserm-00722692Le document en format XML
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<desc> <address> <addrLine>20 Avenue du Stade de France93218 La Plaine Saint Denis</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.dondusang.net</ref>
</desc>
</hal:affiliation>
<country>France</country>
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</author>
<author><name sortKey="Morel, Pascal" sort="Morel, Pascal" uniqKey="Morel P" first="Pascal" last="Morel">Pascal Morel</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-199980" status="VALID"> <orgName>Etablissement Français du Sang [La Plaine Saint-Denis]</orgName>
<orgName type="acronym">EFS</orgName>
<desc> <address> <addrLine>20 Avenue du Stade de France93218 La Plaine Saint Denis</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.dondusang.net</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Valette, Martine" sort="Valette, Martine" uniqKey="Valette M" first="Martine" last="Valette">Martine Valette</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-92345" status="VALID"> <orgName>Centre National de Référence Virus Influenza (Région Sud)</orgName>
<desc> <address> <addrLine>Lyon</addrLine>
<country key="FR"></country>
</address>
</desc>
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<tutelles><tutelle active="#struct-300074" type="direct"><org type="regroupinstitution" xml:id="struct-300074" status="VALID"> <idno type="IdRef">026534657</idno>
<orgName>Hospices Civils de Lyon</orgName>
<orgName type="acronym">HCL</orgName>
<desc> <address> <addrLine>3 Quai des Célestins69002 Lyon </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Enouf, Vincent" sort="Enouf, Vincent" uniqKey="Enouf V" first="Vincent" last="Enouf">Vincent Enouf</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-109174" status="OLD"> <orgName>Génétique moléculaire des virus à ARN</orgName>
<desc> <address> <addrLine>25-28 rue du Docteur Roux, F-75724 Paris Cedex 15</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300027" type="direct"></relation>
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<tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno>
<idno type="ISNI">0000 0001 2353 6535</idno>
<orgName>Institut Pasteur [Paris]</orgName>
<date type="start">1887-06-04</date>
<desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.pasteur.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="URA3015" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Jacquot, Eric" sort="Jacquot, Eric" uniqKey="Jacquot E" first="Eric" last="Jacquot">Eric Jacquot</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-199980" status="VALID"> <orgName>Etablissement Français du Sang [La Plaine Saint-Denis]</orgName>
<orgName type="acronym">EFS</orgName>
<desc> <address> <addrLine>20 Avenue du Stade de France93218 La Plaine Saint Denis</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.dondusang.net</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Pelletier, Bertrand" sort="Pelletier, Bertrand" uniqKey="Pelletier B" first="Bertrand" last="Pelletier">Bertrand Pelletier</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-199980" status="VALID"> <orgName>Etablissement Français du Sang [La Plaine Saint-Denis]</orgName>
<orgName type="acronym">EFS</orgName>
<desc> <address> <addrLine>20 Avenue du Stade de France93218 La Plaine Saint Denis</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.dondusang.net</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Le Strat, Yann" sort="Le Strat, Yann" uniqKey="Le Strat Y" first="Yann" last="Le Strat">Yann Le Strat</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300053" status="VALID"> <orgName>Institut de Veille Sanitaire </orgName>
<orgName type="acronym">INVS</orgName>
<desc> <address> <addrLine>12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France</addrLine>
<country key="FR"></country>
</address>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Pillonel, Josiane" sort="Pillonel, Josiane" uniqKey="Pillonel J" first="Josiane" last="Pillonel">Josiane Pillonel</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300053" status="VALID"> <orgName>Institut de Veille Sanitaire </orgName>
<orgName type="acronym">INVS</orgName>
<desc> <address> <addrLine>12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France</addrLine>
<country key="FR"></country>
</address>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Fonteneau, Laure" sort="Fonteneau, Laure" uniqKey="Fonteneau L" first="Laure" last="Fonteneau">Laure Fonteneau</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300053" status="VALID"> <orgName>Institut de Veille Sanitaire </orgName>
<orgName type="acronym">INVS</orgName>
<desc> <address> <addrLine>12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France</addrLine>
<country key="FR"></country>
</address>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-109174" status="OLD"> <orgName>Génétique moléculaire des virus à ARN</orgName>
<desc> <address> <addrLine>25-28 rue du Docteur Roux, F-75724 Paris Cedex 15</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300027" type="direct"></relation>
<relation name="URA3015" active="#struct-441569" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno>
<idno type="ISNI">0000 0001 2353 6535</idno>
<orgName>Institut Pasteur [Paris]</orgName>
<date type="start">1887-06-04</date>
<desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.pasteur.fr</ref>
</desc>
</org>
</tutelle>
<tutelle name="URA3015" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno>
<idno type="ISNI">0000000122597504</idno>
<orgName>Centre National de la Recherche Scientifique</orgName>
<orgName type="acronym">CNRS</orgName>
<date type="start">1939-10-19</date>
<desc> <address> <country key="FR"></country>
</address>
<ref type="url">http://www.cnrs.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Lina, Bruno" sort="Lina, Bruno" uniqKey="Lina B" first="Bruno" last="Lina">Bruno Lina</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-92345" status="VALID"> <orgName>Centre National de Référence Virus Influenza (Région Sud)</orgName>
<desc> <address> <addrLine>Lyon</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-300074" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-300074" type="direct"><org type="regroupinstitution" xml:id="struct-300074" status="VALID"> <idno type="IdRef">026534657</idno>
<orgName>Hospices Civils de Lyon</orgName>
<orgName type="acronym">HCL</orgName>
<desc> <address> <addrLine>3 Quai des Célestins69002 Lyon </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Tiberghien, Pierre" sort="Tiberghien, Pierre" uniqKey="Tiberghien P" first="Pierre" last="Tiberghien">Pierre Tiberghien</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-199980" status="VALID"> <orgName>Etablissement Français du Sang [La Plaine Saint-Denis]</orgName>
<orgName type="acronym">EFS</orgName>
<desc> <address> <addrLine>20 Avenue du Stade de France93218 La Plaine Saint Denis</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.dondusang.net</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Levy Bruhl, Daniel" sort="Levy Bruhl, Daniel" uniqKey="Levy Bruhl D" first="Daniel" last="Lévy-Bruhl">Daniel Lévy-Bruhl</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300053" status="VALID"> <orgName>Institut de Veille Sanitaire </orgName>
<orgName type="acronym">INVS</orgName>
<desc> <address> <addrLine>12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France</addrLine>
<country key="FR"></country>
</address>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1371/journal.pone.0033056</idno>
<series><title level="j">PLoS ONE</title>
<idno type="ISSN">1932-6203</idno>
<imprint><date type="datePub">2012</date>
</imprint>
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<front><div type="abstract" xml:lang="en"> <p>BACKGROUND: Knowledge of the age-specific prevalence of seroprotection and incidence of seroconversion infection is necessary to complement clinical surveillance data and statistical models. It provides the basis for estimating the future impact of influenza A (H1N1pdm09) and implementing appropriate prevention and response strategies. METHODS: Using a cross-sectional design, two-stage stratified sampling and paired plasma samples, we estimated the age-specific prevalence of a protective level of H1N1pdm09 antibodies in the French adult population before and after the 2009/10 pandemic, and the proportion of those susceptible that seroconverted due to infection, from a single sample of 1,936 blood donors aged 20-70 years in mainland France in June 2010. Samples with a haemagglutination inhibition (HI) titre ≥1∶40 were considered seropositive, and seroconversion due to infection was defined as a 4-fold increase in titre in the absence of H1N1pdm09 vaccination or pre-pandemic seropositivity. RESULTS: Out of the 1,936 donors, 1,708 were included in the analysis. Seroprevalence before the pandemic was 6.7% (95% CI 5.0, 8.9) with no significant differences by age-group (p = 0.3). Seroprevalence afterwards was 23.0% (95% CI 17.7, 29.3) with 20-29 year olds having a higher level than older groups (p<0.001). Seroconversion due to infection was 12.2% (95% CI 6.9, 20.5). Younger age-group, vaccination against H1N1 and being seropositive before the pandemic were strongly associated with post-pandemic seropositivity. CONCLUSIONS: Before the 2009/2010 winter influenza season, only 6.7% of the French mainland population aged 20-70 had a level of antibodies usually considered protective. During the first pandemic wave, 12.2% of the population seroconverted due to infection and the seroprevalence after the wave rose to 23%, either due to prepandemic seropositivity, infection or vaccination. This relatively low latter figure contributed to an extension of target groups for influenza vaccination for the 2010/2011 season.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Bone, Angie" sort="Bone, Angie" uniqKey="Bone A" first="Angie" last="Bone">Angie Bone</name>
</noRegion>
<name sortKey="Assal, Azzedine" sort="Assal, Azzedine" uniqKey="Assal A" first="Azzedine" last="Assal">Azzedine Assal</name>
<name sortKey="Degeorges, Armelle" sort="Degeorges, Armelle" uniqKey="Degeorges A" first="Armelle" last="Degeorges">Armelle Degeorges</name>
<name sortKey="Enouf, Vincent" sort="Enouf, Vincent" uniqKey="Enouf V" first="Vincent" last="Enouf">Vincent Enouf</name>
<name sortKey="Fonteneau, Laure" sort="Fonteneau, Laure" uniqKey="Fonteneau L" first="Laure" last="Fonteneau">Laure Fonteneau</name>
<name sortKey="Guthmann, Jean Paul" sort="Guthmann, Jean Paul" uniqKey="Guthmann J" first="Jean-Paul" last="Guthmann">Jean-Paul Guthmann</name>
<name sortKey="Jacquot, Eric" sort="Jacquot, Eric" uniqKey="Jacquot E" first="Eric" last="Jacquot">Eric Jacquot</name>
<name sortKey="Le Strat, Yann" sort="Le Strat, Yann" uniqKey="Le Strat Y" first="Yann" last="Le Strat">Yann Le Strat</name>
<name sortKey="Levy Bruhl, Daniel" sort="Levy Bruhl, Daniel" uniqKey="Levy Bruhl D" first="Daniel" last="Lévy-Bruhl">Daniel Lévy-Bruhl</name>
<name sortKey="Lina, Bruno" sort="Lina, Bruno" uniqKey="Lina B" first="Bruno" last="Lina">Bruno Lina</name>
<name sortKey="Morel, Pascal" sort="Morel, Pascal" uniqKey="Morel P" first="Pascal" last="Morel">Pascal Morel</name>
<name sortKey="Pelletier, Bertrand" sort="Pelletier, Bertrand" uniqKey="Pelletier B" first="Bertrand" last="Pelletier">Bertrand Pelletier</name>
<name sortKey="Pillonel, Josiane" sort="Pillonel, Josiane" uniqKey="Pillonel J" first="Josiane" last="Pillonel">Josiane Pillonel</name>
<name sortKey="Rousset, Dominique" sort="Rousset, Dominique" uniqKey="Rousset D" first="Dominique" last="Rousset">Dominique Rousset</name>
<name sortKey="Tiberghien, Pierre" sort="Tiberghien, Pierre" uniqKey="Tiberghien P" first="Pierre" last="Tiberghien">Pierre Tiberghien</name>
<name sortKey="Valette, Martine" sort="Valette, Martine" uniqKey="Valette M" first="Martine" last="Valette">Martine Valette</name>
<name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
</country>
</tree>
</affiliations>
</record>
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